J. Hoek, Daniël Colonius (1566-1635). Theoloog tussen reformatie en orthodoxie

Op-gbev130114 1555..1566

Sex chromosome divergence, which follows the cessation of recombination and degeneration of the sex-limited chromosome, can cause a reduction in expression level for sex-linked genes in the heterozygous sex, unless some mechanisms of dosage compensation develops to counter the reduction in gene dose. Because large-scale perturbations in expression levels arising from changes in gene dose might ...

Dmm022020 1635..1641

The choline-deficient, ethionine-supplemented (CDE) dietary model induces chronic liver damage, and stimulates liver progenitor cell (LPC)-mediated repair. Long-term CDE administration leads to hepatocellular carcinoma in rodents and lineage-tracing studies show that LPCs differentiate into functional hepatocytes in this model. The CDE diet was first modified for mice by our laboratory by separ...

Dmd058123 1556..1566

Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line. An inflammation state was induced by a 24-hour exposure to proinflammatory cytokines interleukin-6 (IL-6) and IL-1b; then ...

1566 La Pradera Dr

1566 Human Neutrophil

The capacity of humoral factors to influence polymorphonuelear leukocyte function has been recognized by in vitro studies. Neutrophil phagocytosis is enhanced by the presence of a fragment of the third component of complement, C3b, on a target cell or complex (1). Neutrophils respond chemotacticallv in vitro to by-products of the complement reaction sequence such as the cleavage product of the ...